abstract：BACKGROUND:The continuing increase in the rate of penicillin and cephalosporin resistance among respiratory pathogens and of cross-resistance to macrolide antibiotics has led to the recommendation that fluoroquinolone antibiotics be used to treat high-risk patients with community-acquired pneumonia (CAP) and acute bact...

journal_title：Clinical therapeutics

authors： Schentag JJ

更新日期：2000-04-01 00:00:00

abstract：OBJECTIVE:The goal of this health economic analysis was to asses the cost-effectiveness of a fixed combination of aspirin plus extended-release dipyridamole (ASA/ER-DP) or clopidogrel compared with ASA monotherapy for prevention of recurrent ischemic stroke. BACKGROUND:The second European Stroke Prevention Study (ASA/...

journal_title：Clinical therapeutics

authors： Shah H,Gondek K

更新日期：2000-03-01 00:00:00

abstract：OBJECTIVE:This meta-analysis was performed to assess the possible prophylactic benefit of prolonged treatment with oral N-acetylcysteine (NAC) in chronic bronchitis (CB) based on qualifying clinical trials. Treatment of acute exacerbations with NAC was not investigated. BACKGROUND:Prolonged treatment with oral NAC has...

journal_title：Clinical therapeutics

authors： Grandjean EM,Berthet P,Ruffmann R,Leuenberger P

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND:Patients with glaucoma or ocular hypertension may have inadequately controlled intraocular pressure (IOP) or experience adverse effects with their current medication regimens. OBJECTIVE:This post hoc reanalysis determined the effectiveness and tolerability of brimonidine used as replacement therapy in a rea...

journal_title：Clinical therapeutics

authors： Lee DA

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Sirolimus, a new immunosuppressive agent, has recently been approved in the United States for use in combination with cyclosporine and corticosteroids in renal allograft transplantation. Therapeutic drug monitoring (TDM) of sirolimus is advocated by the drug's manufacturer in certain patient populations. Giv...

journal_title：Clinical therapeutics

authors： Napoli KL

更新日期：2000-01-01 00:00:00

abstract：:This paper describes a study of drug use and drug-related problems in community-dwelling elderly (> or =65 years) Medicaid recipients in Maryland, Iowa, and Washington from 1989 through 1996. A claim-by-claim review of Medicaid prescriptions was conducted to detect 5 types of prescribing problems (dose, duration of th...

journal_title：Clinical therapeutics

authors： Briesacher BA,Stuart B,Peluso R

更新日期：1999-12-01 00:00:00

abstract：:The pharmacodynamic parameter that appears to correlate best with a successful therapeutic outcome with beta-lactam antibiotics is the length of time the serum antibiotic concentration remains above the minimum inhibitory concentration (MIC) for the infecting pathogen. By maximizing this parameter, continuous administ...

journal_title：Clinical therapeutics

authors： Burgess DS,Summers KK,Hardin TC

更新日期：1999-11-01 00:00:00

abstract：:General health-status questionnaires such as the Medical Outcomes Study 36-Item Short Form Health Survey (SF-36) are frequently used to measure health-related quality of life. The SF-36, in its current form, cannot be used to measure individuals' utilities or preferences for their health state. Recently, several inves...

journal_title：Clinical therapeutics

authors： Meletiche DM,Doshi D,Lofland JH

更新日期：1999-11-01 00:00:00

abstract：:Prolonged, repeated use of nasal decongestants for symptomatic relief of allergic rhinitis often results in rhinitis medicamentosa (RM), a condition involving "rebound swelling" and additional congestion. Most decongestant sprays contain the preservative benzalkonium chloride (BKC), which causes toxic reactions in the...

journal_title：Clinical therapeutics

authors： Graf P

更新日期：1999-10-01 00:00:00

abstract：:The objective of this 12-week, double-masked, randomized, multicenter study was to compare the elastoviscous properties of a high-molecular-weight viscosupplement, hylan G-F 20 (polymer concentration, 0.8%), with those of a lower-molecular-weight hyaluronan (LMW HA) product (polymer concentration, 1%) and to determine...

journal_title：Clinical therapeutics

authors： Wobig M,Bach G,Beks P,Dickhut A,Runzheimer J,Schwieger G,Vetter G,Balazs E

更新日期：1999-09-01 00:00:00

abstract：:Antihypertensive drugs are commonly prescribed for the treatment of patients with both diabetes and hypertension. However, the role of selected agents in the development of hypoglycemia remains controversial. The main objective of this study was to evaluate the effect of antihypertensive agents on the risk of hypoglyc...

journal_title：Clinical therapeutics

authors： Thamer M,Ray NF,Taylor T

更新日期：1999-08-01 00:00:00

abstract：:This study compared the cost-effectiveness of donepezil, a new cholinesterase inhibitor indicated for the treatment of mild-to-moderate probable Alzheimer's disease (AD), with no treatment. A Markov state transition model was employed to simulate treatment costs based on Swedish epidemiologic data. The Markov states u...

journal_title：Clinical therapeutics

authors： Jönsson L,Lindgren P,Wimo A,Jönsson B,Winblad B

更新日期：1999-07-01 00:00:00

abstract：:The optimal antibiotic therapy for patients with acute bacterial exacerbations of chronic bronchitis (ABECB) who have failed to respond to previous oral antimicrobial therapy is not known; however, newer macrolide and fluoroquinolone antibiotics may be appropriate. This multicenter, randomized, double-masked, double-d...

journal_title：Clinical therapeutics

authors： Lipsky BA,Unowsky J,Zhang H,Townsend L,Talbot GH

更新日期：1999-06-01 00:00:00

abstract：:This pilot study was conducted to compare both the clinical effectiveness and the treatment costs of newer (atypical) antipsychotic medications (clozapine and risperidone) with those of older (classic) neuroleptic medications (chlorpromazine and haloperidol) for psychosis in a community mental health care setting. The...

journal_title：Clinical therapeutics

authors： Galvin PM,Knezek LD,Rush AJ,Toprac MG,Johnson B

更新日期：1999-06-01 00:00:00

abstract：:The management of patients with congestive heart failure (CHF) can place a significant economic burden on managed care organizations, leading providers to seek treatments that are cost-effective. Diuretics play a significant role in the treatment of edema associated with CHF. We evaluated the use of 2 loop diuretics, ...

journal_title：Clinical therapeutics

authors： Noe LL,Vreeland MG,Pezzella SM,Trotter JP

更新日期：1999-05-01 00:00:00

abstract：:Detrusor instability, or urinary incontinence, is common in elderly patients, particularly elderly women. The clinical symptoms of overactive, or unstable, urinary bladder include urge urinary incontinence, urgency, and frequency. Mixed urinary incontinence, which comprises urge urinary incontinence and stress inconti...

journal_title：Clinical therapeutics

authors： Goldenberg MM

更新日期：1999-04-01 00:00:00

abstract：:In its clinical assessment of the respiratory syncytial virus (RSV)-specific monoclonal antibody palivizumab, the IMpact-RSV Study Group demonstrated a reduction in hospitalizations for RSV-related lower respiratory tract infection in infants who received prophylaxis compared with infants who did not receive prophylax...

journal_title：Clinical therapeutics

authors： Marchetti A,Lau H,Magar R,Wang L,Devercelli G

更新日期：1999-04-01 00:00:00

abstract：:Moxifloxacin (BAY 12-8039) is an investigational 8-methoxy-fluoroquinolone with broad-spectrum gram-positive and gram-negative activity. To determine the absolute bioavailability of moxifloxacin, this open-label, randomized, crossover study compared the pharmacokinetic characteristics of a single 100-mg dose administe...

journal_title：Clinical therapeutics

authors： Ballow C,Lettieri J,Agarwal V,Liu P,Stass H,Sullivan JT

更新日期：1999-03-01 00:00:00

abstract：:Coexisting diseases may have unforeseen yet clinically significant effects on patients' well-being. Both generic and disease-specific measures are frequently used to assess health-related quality of life (QOL). The present study assessed the effects of comorbidity on the results of QOL measures through an analysis of ...

journal_title：Clinical therapeutics

authors： Xuan J,Kirchdoerfer LJ,Boyer JG,Norwood GJ

更新日期：1999-02-01 00:00:00

abstract：:Inhibitors of platelet glycoprotein (GP) IIb-IIIa have been demonstrated to be effective in controlling acute cardiac complications in patients presenting with acute ischemic coronary syndromes (AICS). Since patients with atherosclerotic coronary vascular disease may present with AICS on multiple occasions, it is impo...

journal_title：Clinical therapeutics

authors： Lorenz TJ,Macdonald F,Kitt MM

更新日期：1999-01-01 00:00:00

abstract：:In a multicenter, parallel-group, double-masked, randomized study, two questionnaires were administered to a clinical study population to identify which specific symptoms of seasonal allergic rhinitis patients perceived as most important to relieve (personal preferences) and to learn whether any relationship existed b...

journal_title：Clinical therapeutics

authors： Ricard N,Kind P,Christian S,Jensen M,Stewart J

更新日期：1999-01-01 00:00:00

abstract：:This paper briefly reviews the extent of current drug coverage for Medicare beneficiaries and describes the most important issues faced by aged beneficiaries who receive or seek drug coverage through a Medicare managed care plan. Changes in payment rates to these plans as a result of the Balanced Budget Act of 1997 ma...

journal_title：Clinical therapeutics

authors： Williams K

更新日期：1998-11-01 00:00:00

abstract：:We compared the efficacy of timolol maleate ophthalmic gel-forming solution 0.5% QD with that of levobunolol hydrochloride 0.5% BID, as measured by change in intraocular pressure (IOP), effect on heart rate, and ocular tolerability. The study had a positive-controlled, double-masked, randomized, multicenter, 12-week, ...

journal_title：Clinical therapeutics

authors： Walters TR,Maloney S,Slater D,Liss C,Wilson H,Hartenbaum D

更新日期：1998-11-01 00:00:00

abstract：:Lyme disease produces a diverse clinical picture that can include serious and potentially debilitating cardiac, neurologic, joint, and skin involvement. It is characterized in three stages--early localized (stage I), early disseminated (stage II), and late disseminated (stage III)--and medical management is highly dep...

journal_title：Clinical therapeutics

authors： Maes E,Lecomte P,Ray N

更新日期：1998-09-01 00:00:00

abstract：:The objective of this study was to assess a weight-based heparin (WBH) nomogram (80-U/kg bolus, 18-U/kg-per-hour initial infusion) and determine its clinical performance and impact on resource utilization. All patients treated with heparin for venous thromboembolism or unstable angina during a 15-week study period wer...

journal_title：Clinical therapeutics

authors： Lackie CL,Luzier AB,Donovan JA,Feras HI,Forrest A

更新日期：1998-07-01 00:00:00

abstract：:Community-acquired pneumonia (CAP) is responsible for an average of 4.5 million visits annually to physicians' offices, emergency departments, and outpatient clinics. However, there have been few studies using national data on the costs of treating CAP. Without such data, it is difficult to assess whether new therapie...

journal_title：Clinical therapeutics

authors： Niederman MS,McCombs JS,Unger AN,Kumar A,Popovian R

更新日期：1998-07-01 00:00:00

abstract：:The purpose of this clinical study was to determine the efficacy, tolerability, and impact on quality of life of domperidone--a specific peripherally acting dopamine antagonist--in the management of symptoms of gastroparesis, a common and potentially debilitating condition in patients with diabetes mellitus. In the fi...

journal_title：Clinical therapeutics

authors： Silvers D,Kipnes M,Broadstone V,Patterson D,Quigley EM,McCallum R,Leidy NK,Farup C,Liu Y,Joslyn A

更新日期：1998-05-01 00:00:00

abstract：:The purpose of this study was to estimate the impact of the introduction of propentofylline, a glial-cell modulator with neuroprotective properties, on the costs of dementia care in Sweden. To estimate the clinical effects of propentofylline treatment on dementia, we conducted a meta-analysis of four double-masked, pl...

journal_title：Clinical therapeutics

authors： Wimo A,Witthaus E,Rother M,Winblad B

更新日期：1998-05-01 00:00:00

abstract：:Cisapride is a substituted piperidinyl benzamide. It is chemically related to metoclopramide but lacks the antidopaminergic properties of metoclopramide that affect the central nervous system and cause extrapyramidal side effects. Cisapride is indicated for the symptomatic treatment of patients with nocturnal heartbur...

journal_title：Clinical therapeutics

authors： Zhou H,Herron J,Clyde C,Lee P,Mechlinski W,Pesco-Koplowitz L

更新日期：1998-03-01 00:00:00

abstract：:Health care provision in the United States is driven by the fact that most health insurance is commercial and private. This leads to the tendency to view patients as units that will produce a future cash yield. The quality of life (QOL) movement in the United States is in some ways a response to this view and has a ro...

journal_title：Clinical therapeutics

authors： Leppik IE

更新日期：1998-01-01 00:00:00

abstract：:Recently published guidelines for the treatment of dyspepsia have emphasized the importance of age, Helicobacter pylori infection, and alarm symptoms such as weight loss, anemia, and dysphagia in patient assessment. However, the currently available guidelines were not designed specifically for regions in which the inc...

journal_title：Clinical therapeutics

authors： Matsueda K

更新日期：1998-01-01 00:00:00

abstract：:The monomeric insulin analogue insulin lispro (Lys B28, Pro B29) is a rapid-acting insulin with a shorter duration of activity than human regular insulin. This compound has the advantage of reducing early postprandial hyperglycemia and the accompanying late hypoglycemia, thereby improving overall blood glucose control...

journal_title：Clinical therapeutics

authors： Somwar R,Sweeney G,Ramlal T,Klip A

更新日期：1998-01-01 00:00:00

abstract：:Self-care with over-the-counter (OTC) medicines has evolved from the "dark ages" of patent medicine manufacture and sale to a modern era of new drug development involving prescription-to-OTC switch. This evolution is largely due to the OTC Review, which placed science at the cornerstone of safety, effectiveness, and l...

journal_title：Clinical therapeutics

authors： Soller RW

更新日期：1998-01-01 00:00:00

abstract：:The United States Pharmacopeia (USP) Practitioners' Reporting Network utilized nearly three decades of experience to design and develop a nationwide, anonymous, Internet-accessible service for hospitals to report and benchmark medication errors (also known as "preventable adverse drug events"). As nationwide experient...

journal_title：Clinical therapeutics

authors： Cousins DD

更新日期：1998-01-01 00:00:00

abstract：:Patients with seasonal or allergic bronchial asthma experience an immediate allergic response caused by allergen-specific immunoglobulin E-mediated histamine release. The release of histamine and other chemical mediators may trigger airway hyperresponsiveness and exaggerated bronchoconstriction, characteristic feature...

journal_title：Clinical therapeutics

authors： Menardo JL,Horak F,Danzig MR,Czarlewski W

更新日期：1997-11-01 00:00:00

abstract：:As policy makers explore ways to reform the Medicare system, the inevitable question of prescription drug coverage for the elderly will surface. This is an opportunity to revisit and balance the attractiveness of including a prescription benefit against the fear of increases in expenditures. Prudent examination of the...

journal_title：Clinical therapeutics

authors： McKercher PL

更新日期：1997-11-01 00:00:00

abstract：:This paper explores how one health care purchasing coalition in Minnesota, the Buyers Health Care Action Group (BHCAG), has taken an active role in restructuring its local health care market. BHCAG started with the belief that the consumer should be the motivating force in health care delivery. Unfortunately, providin...

journal_title：Clinical therapeutics

authors： Robinow A

更新日期：1997-11-01 00:00:00

abstract：:Hydroxychloroquine (HCQ), an antimalarial agent used to treat patients with autoimmune diseases, has been shown to suppress human immunodeficiency virus type 1 (HIV-1) replication in T cells and monocytes in vitro by inhibiting posttranscriptional modification of the virus. An initial randomized, placebo-controlled cl...

journal_title：Clinical therapeutics

authors： Sperber K,Chiang G,Chen H,Ross W,Chusid E,Gonchar M,Chow R,Liriano O

更新日期：1997-09-01 00:00:00

abstract：:Idiopathic chronic hiccup (ICH) is defined as recurring hiccup attacks that last for longer than an arbitrary time limit (eg, 1 month) and for which no organic cause can be found. In patients with ICH, therapy is largely empiric. For practical purposes, idiopathic hiccup can be assumed to have its origin either in the...

journal_title：Clinical therapeutics

authors： Petroianu G,Hein G,Petroianu A,Bergler W,Rüfer R

更新日期：1997-09-01 00:00:00

abstract：:This tenth anniversary review/update of fluoxetine concentrates on the past 5 years of its clinical application. The mechanism of action of fluoxetine; its metabolism; its efficacy in patients with various diagnostic subgroups of depression, patients with coincident medical disease, children and adolescents with depre...

journal_title：Clinical therapeutics

authors： Stokes PE,Holtz A

更新日期：1997-09-01 00:00:00